Matrix Metalloproteinase-3 Kit
PANACLEAR MMP-3 [Latex]
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- Reference Data
PANACLEAR®MMP-3 Latex is a reagent to measure MMP-3 (matrix metalloproteinase-3) in serum or plasma.
Because the reagent is applicable to clinical automated analyzers, simplified and accurate measurement is possible.
Features
- Liquid reagent applicable to clinical automated analyzers.
- Intended for the Latex turbidimetric immunoassay.
What is MMP-3?
Because MMP-3 is produced by synovial cells and chondrocytic cells, and its specific substrate is proteoglycan, which consists of cartilage, it is being studied as an enzyme that may be involved in the destruction of articular tissues in articular rheumatism (RA). Generally, synovial membranes exhibit an inflammatory reaction and proliferate as the RA status progresses. With this growth of the membranes, MMP-3 is developed and produced in lamellar synovial cells. Its matrix decomposition action is thought to cause articular destruction. MMP-3 produced in lamellar synovial cells is stored in joint fluids, and transferred into blood via blood vessels or lymph vessels. This is a possible scheme underlying the increase of the MMP-3 level in blood.
Because of this behavior of MMP-3 in the body, the MMP-3 level in blood has the potential for becoming a prognostic indicator or predictor of outgrowths of synovial membranes in early RA and joint destruction.
References
- Prognosis and prediction of patients' articular rheumatism and meaning of measurement of serum MMP-3 [136KB]
- A new way of looking at rheumatism [600KB]
- Therapy method for rheumatism [544KB]
- Comparison of patients' backgrounds between ACR70 responders and nonresponders two weeks after administration of Infliximab [636KB]
Measurement Principle
Description
| Name | Package | Shelf-life | Storage | |
|---|---|---|---|---|
| PANACLEAR®MMP-3 Latex | Buffer solution (1) | 30mL×2 | 12 months | 2-10°C |
| PANACLEAR®MMP-3 Latex | Latex reagent (2) | 10mL×2 | 12 months | 2-10°C |
| MMP-3 Calibrator* | For 1mL×5 conc. | 17 months | 2-10°C | |
| MMP-3 Control* | For 1mL×4 | 17 months | 2-10°C | |
| MMP-3 Sample dilution solution* | 2mL | 8 months | 2-10°C | |
*These are not an in vitro diagnostic reagent.
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