Haloperidol Kit/Bromperidol Kit
CEDIA-HAL/BRP
- INDEX
-
- Products Top Page
- Correlation with HPLC Method
- Reference Data
Measurement Principle
- CEDIA (Cloned Enzyme Donor Immunoassay) method(Homogeneous enzyme-linked immuno-solvent assay)
- Applicable to various types of automated analyzers
Cross-reactivity
| Haloperidol | Concentration
(ng/mL) |
Crossover rate (%) |
|
|---|---|---|---|
| Metabolites | Reduced haloperidol | 1,000 | 1.7 |
| 4-Fluorophenylpropionic acid | 100,000 | <0.01 | |
| 4-Fluorophenylacetic acid | 100,000 | <0.01 | |
| 4-Fluorophenylaceturic acid | 100,000 | <0.01 | |
| 4-Hydroxy-4-(p-chlorophenyl) piperidine | 100,000 | <0.01 | |
| Similar drugs | Bromperidol | 40 | 114 |
| Reduced bromperidol | 1,000 | 0.9 | |
| Haloperidol decanoate | 1,000 | 1.2 | |
| Benperidol | 500 | 6.2 | |
| Moperone | 60 | 50.8 | |
| Timiperone | 500 | 4.9 | |
| Other drugs | Levomepromazine | 100,000 | <0.01 |
| Chlorpromazine | 100,000 | <0.01 | |
| Zotepine | 100,000 | <0.01 | |
| Risperidone | 100,000 | <0.01 | |
| Biperiden | 100,000 | <0.01 | |
| Trihexyphenidyl hydrochloride | 100,000 | <0.01 | |
| Nitrazepam | 20,000 | <0.01 |
| Bromperidol | Concentration (ng/mL) |
Crossover rate (%) |
|
|---|---|---|---|
| Metabolites | Reduced bromperidol | 1,000 | 0.9 |
| 4-Fluorophenylpropionic acid | 100,000 | <0.01 | |
| 4-Fluorophenylacetic acid | 100,000 | <0.01 | |
| 4-Fluorophenylaceturic acid | 100,000 | <0.01 | |
| 4-Hydroxy-4-(p-chlorophenyl) piperidine | 100,000 | <0.01 | |
| Similar drugs | Haloperidol | 40 | 97.5 |
| Reduced haloperidol | 1,000 | 1.5 | |
| Haloperidol decanoate | 1,000 | 1.1 | |
| Benperidol | 500 | 5.6 | |
| Moperone | 60 | 46.4 | |
| Timiperone | 500 | 4.5 | |
| Other drugs | Levomepromazine | 100,000 | <0.01 |
| Chlorpromazine | 100,000 | <0.01 | |
| Zotepine | 100,000 | <0.01 | |
| Risperidone | 100,000 | <0.01 | |
| Biperiden | 100,000 | <0.01 | |
| Trihexyphenidyl hydrochloride | 100,000 | <0.01 | |
| Nitrazepam | 20,000 | <0.01 |
The structure of haloperidol closely resembles that of bromperidol (the atom at the terminus of the side chain is Cl for haloperidol and Br for bromperidol). Accordingly, both substances have similar reactivities to CEDIA-HAL/BRP, so a sample that contains both haloperidol and bromperidol doesn't provides accurate measured data for each.
Example of Assay Diagram
We have applications suitable for various types of automated analyzers available. For assistance with applications on automated analyzers, please contact us.
Before measurement of haloperidol, perform calibration using a CEDIA haloperidol Calibrator. Before measurement of bromperidol, perform calibration using a CEDIA bromperidol Calibrator.
Measurement range
- Haloperidol: 1.25-40ng/mL
- Bromperidol: 1.25-40ng/mL
Examples of Optimum Concentrations in Blood
Therapeutic window
- Haloperidol: 5.6-16.9ng/mL3)* 5-15ng/mL4) (GC)
- Bromperidol: 4.0-14.3ng/mL5) (HPLC)
Sufficient concentration by therapeutic plateau
- Haloperidol: 13ng/mL6) (HPLC)
- Bromperidol: 12ng/mL7) (HPLC)
*By meta-analysis (HPLC, GC, RIA)
Shelf Life of Reconstituted Reagents
60 days at 2-8°C
References
- Shinya Sakamoto, et al: Nihon Rinsho, Extra number 57, 380 (1999)
- Norio Yasui-Furukori: Submitted
- Ulrich S, et al: Clin Pharmacokinet 34, 227 (1998)
- Irl Extein, et al: Psychopharmacology bulletin 18, 156 (1982)
- Tetsuro Takagi, et al: Japanese Journal of Clinical and Experimental Medicine, 66, 2670 (1989)
- Toshiyuki Someya, et al: Neuropsychopharmacology 18, 511 (1996)
- Kazuyuki Fujita, et al: Psychiatric therapeutics 16, 581 (2001)
- TDM (drug level in blood) Product List
We prepared this page for medical staff (doctors, dentists, pharmacists, clinical laboratory technicians, nurses, etc.) in Japan to ensure the correct use of our products. You should be aware that the information provided is not intended for overseas medical staff and the general public.
