Pharmacological Study
We conduct pharmacological studies on drug safety as well as on drug efficacy using animal tissues and human recombinant proteins (receptor), enzymes and cells in compliance with the Quality Assurance Standards.
Study Topics
- Study to support the efficacy of a drug
- Secondary pharmacological study of a drug (profiling)
- Selectivity study for receptor subtypes of a drug
- Study to identify the mode of action of a drug (agonist, antagonist and inverse agonist)
- Binding-dissociation study of a drug
- Study to identify the mechanism of action of a drug on its receptor
- Receptor analysis study with drug administration
- Receptor analysis study by imaging
- Study for internalization into cells and inhibition of cytokine production
Measurement system
Binding assay (radio receptor assay; RRA)
264 measurement systems are ready for use.
We conduct various studies using animal tissues and human recombinant proteins. We will address your request for change in a measurement system or for the development of a measurement system.
Functional assay
38 measurement systems are ready for use.
The mode of action of a drug (agonist, antagonist and inverse agonist) can be identified by a measurement system with GTPγ-S.
Enzyme inhibition assay
15 measurement systems are ready for use.
We will use any measurement system not listed here. Please ask us for details.
Kinase inhibition assay
166 measurement systems are ready for use.
Immunoassay
74 measurement systems are ready for use.
We measure various endogenous substances as drug effect markers.
Cell base assay
We will conduct studies for binding to cell membrane, incorporation of a drug into cells and its degradation, effect on cell proliferation, internalization, inhibition of cytokine production, etc., using cells isolated from tissues, commercially available cells or cells provided by the customer. Please ask us for details.