Performs custom synthesis of labelled compounds, and assessment of tests related to pharmacokinetics. ADME & Tox. Research Business of SEKISUI MEDICAL.

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Pharmacological Study

We conduct pharmacological studies on drug safety as well as on drug efficacy using animal tissues and human recombinant proteins (receptor), enzymes and cells in compliance with the Quality Assurance Standards.

Study Topics

  • Study to support the efficacy of a drug
  • Secondary pharmacological study of a drug (profiling)
  • Selectivity study for receptor subtypes of a drug
  • Study to identify the mode of action of a drug (agonist, antagonist and inverse agonist)
  • Binding-dissociation study of a drug
  • Study to identify the mechanism of action of a drug on its receptor
  • Receptor analysis study with drug administration
  • Receptor analysis study by imaging
  • Study for internalization into cells and inhibition of cytokine production

Measurement system

Binding assay (radio receptor assay; RRA)

231 measurement systems are ready for use.
We conduct various studies using animal tissues and human recombinant proteins. We will address your request for change in a measurement system or for the development of a measurement system.

Functional assay

44 measurement systems are ready for use.
The mode of action of a drug (agonist, antagonist and inverse agonist) can be identified by a measurement system with GTPγ-S.

Enzyme inhibition assay

32 measurement systems are ready for use.
We will use any measurement system not listed here. Please ask us for details.

Kinase inhibition assay

166 measurement systems are ready for use.

Immunoassay

74 measurement systems are ready for use.
We measure various endogenous substances as drug effect markers.

Cell base assay

We will conduct studies for binding to cell membrane, incorporation of a drug into cells and its degradation, effect on cell proliferation, internalization, inhibition of cytokine production, etc., using cells isolated from tissues, commercially available cells or cells provided by the customer. Please ask us for details.

 
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