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What is sIL-2R? (Soluble-Interleukin-2-Receptor)
- Interleukin-2-Receptor (IL-2R) is a protein that is expressed on the cell surface of T and B cells upon activation of by antigen stimulation. IL-2R is composed of 3 chains, alpha, beta, and gamma.
- sIL-2R are alpha chains of the IL-2R which have been cleaved by protease and released into blood.
- sIL-2R value is primarily reflects the degree of T-cell activation.
- Measuring soluble Interleukin-2 Receptor (sIL-2R) can be useful in the aid-in-diagnosis of Non-Hodgkin lymphoma and ATL (adult T-cell leukemia-lymphoma) as well as for the follow-up of patients who have been diagnosed with Non-Hodgkin lymphoma or ATL (adult T-cell leukemia-lymphoma).
- Non-Hodgkin lymphoma and ATL cannot be diagnosed solely with sIL-2R. sIL-2R has mostly been evaluated for its clinical usefulness as a marker for disease activity.
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- Clinical Chemistry
We prepared this page for medical staff (doctors, dentists, pharmacists, clinical laboratory technicians, nurses, etc.) in Japan to ensure the correct use of our products. You should be aware that the information provided is not intended for overseas medical staff and the general public.