Cholestest LDL
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- *Read carefully the package insert before use.
Reference Data (2)
Information obtained using Cholestest LDL
LDL-C is specified as a target value in the primary preventative guidelines for ischemic heart disease of the Japanese Circulation Society, as well as the Japan Atherosclerosis Society.
This product allows measurement unaffected by dietary conditions
Whereas the data obtained using the Friedwald formula (F-formula) are affected by diet because it uses TG values, the data obtained using Cholestest LDL are not.
(Sugano,T.et al: Medicine and Pharmacology, 37, 635, 1997)
Accurate measurement is possible even for TG values of 400 mg/dL and higher-Example (1)
Type V hyperlipidemia (age 52, male)
| LDL-C | Cholestest LDL | 64mg/dL |
|---|---|---|
| F-formula | -5.2mg/dL | |
| TG | Enzymatic method | 886mg/dL |
A high TG value produced a negative result in the F-formula in Example 1 above. Cholestest LDL can accurately determine such high values.
(Excerpt from Case 2 of Case Report for Lipid Examination, supervised by Professor Hiroshige Itakura)
Accurate measurement is possible even for TG values of 400 mg/dL and higher - Example (2)
| LDL-C | Cholestest LDL | 83mg/dL |
|---|---|---|
| F-formula | 176mg/dL | |
| Ultracentrifugation method | 75mg/dL | |
| TG | Enzymatic method | 427mg/dL |
Chylomicron remnants were detected in the agarose electrophoresis in Example 2 above. Cholestest LDL can make accurate measurements even in the presence of chylomicron remnants.
(Excerpt from Case 3 of Case Report for Lipid Examination, supervised by Professor Hiroshige Itakura)
Results directly reflect decreases in LDL-C of patients in therapy
Because an antihyperlipidemic drug lowers LDL-C and increases HDL-C, a reduction of LDL-C is not reflected in the T-CHO values. Variations in LDL-C values are not reflected in the F- formula because of the effects of TG. Decrease in LDL-C values is directly reflected in the Cholestest LDL results.
(From the Saitama Lipid Metabolism Forum, by Doctor Kenji Azuma, Internal Medicine I of the National Defense Medical College)by Azuma, Internal Medicine I of the National Defense Medical College)
LDL particle size can be estimated
As LDL contains one molecule of apo B, its particle size may be estimated from the ratio of LDL-C to apo B (when LDL-C/apo B is 1:2, there is a high probability that small particles exist).
Although apo B also exists in VLDL, the majority (more than 90%) is contained in LDL. Because the small particle LDL is easily oxidized, it causes coronary artery disease at a rate three times higher than other LDL, and therefore is considered to be the worst type of "bad" cholesterol.
(Excerpt from Hirano,T.et al; Prog. Med. 19, 1854, 1999)
"Cholestest" is a trademark or registered trademark of SEKISUI MEDICAL CO., LTD. in Japan and/or other countries.
We prepared this page for medical staff (doctors, dentists, pharmacists, clinical laboratory technicians, nurses, etc.) in Japan to ensure the correct use of our products. You should be aware that the information provided is not intended for overseas medical staff and the general public.