Human Liver-type Fatty Acid Binding Protein (L-FABP) Kit

NORUDIA L-FABP

We created this page for medical staff.

*Read carefully the package insert before use.

About L-FABP

What is L-FABP?

A soluble protein with a molecular weight of 14 kDa found in the proximal renal tubule. It plays an important role in energy and lipid metabolism in the renal tubules, which are responsible for the reabsorption of substances.
When the proximal renal tubule is subjected to ischemia or oxidative stress, expression of L-FABP is elevated, resulting in an increased L-FABP concentration in excreted urine. It is a new biomarker that reflects the severity of stress given to the renal tubule, before progressing to renal tissue damage.

Urinary excretion of L-FABP within the proximal tubule cytoplasm

1 Reactive Oxygen generated due to pertibular ischemia/reperfusion injury change free fatty acid to peroxides(lipoperoxides), which are highly toxic to cells. 2 L-FABP binds with such lipoperoxides and is excreted outside of cells. Thus, L-FABP is thought to be renoprotective.

Difference between L-FABP and conventional renal disease markers

"NORUDIA" is a trademark or registered trademark of SEKISUI MEDICAL CO., LTD. in Japan and/or other countries.

We prepared this page for medical staff (doctors, dentists, pharmacists, clinical laboratory technicians, nurses, etc.) in Japan to ensure the correct use of our products. You should be aware that the information provided is not intended for overseas medical staff and the general public.