Human Liver-type Fatty Acid Binding Protein (L-FABP) Kit

NORUDIA L-FABP

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*Read carefully the package insert before use.

Clinical Significance

1Early diagnosis of renal disease with renal tubular dysfunction.
2L-FABP levels in urine show significant elevation in the early stage of diabetic nephropathy (early detection), and increases/decreases along with progression of the stage or treatment (assessment of therapeutic effect). L-FABP is detected in urine at an earlier stage than microalbumin.
3Assessment of microcirculatory disorder (ischemia). E.g., L-FABP reflects peritubular blood flow that may occur from renal reperfusion due to kidney transplantation.
4Discriminates the presence or absence of the risk of severe Acute Kidney Injury (AKI).

[Diseases associated with abnormal L-FABP values]
Diabetic nephropathy, Chronic Kidney Disease (CKD), Acute Kidney Injury (AKI)

Reference: Guide to Laboratory Tests 2013-2014, Bunkodo Co., Ltd. (revised)

Clinical Data

Acute Kidney Injury(AKI)

Method: 85cardiovascular surgery patients were divided into AKI and non-AKI groups based on the AKIN criteria. Urinary L-FABP and serum CRE were measured chronologically before and after surgery.

Results: With the conventional AKI diagnosis method which uses serum creatinine as an index, AKI symptoms were confirmed >24 hrs after surgery. However, urine L-FABP increased significantly among the AKI patient group immediately after surgery. This comparison indicates that urinary L-FABP is a useful marker for predicting AKI at an early stage.

Diabetic Nephropathy

Method: The urinary L-FABP levels of 140 diabetic nephropathy patients were categorized based on their disease stage. The mean and standard deviation values were calculated and compared to those of healthy individuals.

Results: Urinary L-FABP levels of diabetic nephropathy patients increased with the progress of disease stage. As it showed a significant increase compared to healthy individuals from early stages of nephropathy, it can be said that L-FABP is useful in early diagnosis of diabetic nephropathy.

Diabetic Nephropathy — Reference: Kamijo-Ikemori A, et al. Diabetes Care 34:691-696, 2011

Monitoring of Kidney Disease

Method: ARB was administered to diabetic nephropathy patients for 12 months. Urinary albumin level, urinary L-FABP level, and systolic blood pressure were observed to assess the effects of medical treatment.

Results: Large decrease in urinary albumin level, urinary L-FABP level, and systolic blood pressure were observed after 6 months and 12 months when compared to the start of the treatment. Similar to urinary albumin, urinary L-FABP is effective for the monitoring and assessing the effectiveness of medical treatments, such as antihypertensive therapy, for early-stage diabetic nephropathy.

Monitoring of Kidney Disease — Tsukasa Nakamura, et al. Diabetologia 50(2):490-492, 2007

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